Welcome to the UCSF Viral Diagnostics and Discovery Center (VDDC) and Chiu Laboratory at UCSF China Basin! The UCSF VDDC is a core facility for viral diagnostics arising from a multi-year collaborative agreement between UCSF and Abbott Laboratories.





Precision Diagnosis of Acute Infectious Diseases (PDAID)

Current tests in clinical microbiology fail to diagnose many life-threatening infections in a timely fashion, resulting in increased health care costs and likelihood of death. At UCSF, we have developed and clinically validated a metagenomic next-generation sequencing (mNGS) assay to reveal the cause of unknown infections that commonly elude physicians. This is a "needle-in-a-haystack" approach that allows us to identify all potential pathogens -- viruses, bacteria, fungi, and parasites -- in a single sequencing test. Powered by SURPI for computational analysis, we have as of June 2016 completed clinical laboratory validation of this assay for diagnosis of encephalitis and meningitis from cerebrospinal fluid (CSF). From June 2016 to June 2017, we will enroll and sequence CSF from 300 hospitalized patients in a prospective multi-center study to evaluate the clinical utility and cost-effectiveness of this mNGS laboratory-developed test.

Collaborators on the PDAID study (PI Chiu) include UC Davis, UCLA, Children's Hospital Colorado, Children's Hospital Los Angeles, Children's National Medical Center, St. Jude's Children Research Hospital, UC Berkeley, DNAnexus, Syapse, Google, Quest Diagnostics, Illumina, and the California Department of Public Health. This study is funded by the California Initiative to Advance Precision Medicine and philanthropic grants from the Sandler, Bowes, and Schwab Foundations.




New strain of enterovirus may have caused mystery paralysis
     The New York Times, March 30th, 2015
     NBC News, March 30th, 2015
     The Washington Post, March 30th, 2015
     UCSF, March 30th, 2015
     Wired, March 30th, 2015
     Denver Post, March 30th, 2015


KCBS in-depth: understanding the facts about the Ebola outbreak


Now that Ebola has made its way to the United States, medical experts are working hard to quell fear by offering the facts we know about the virus and how it is spread.


Basic Facts about Ebola


Amid questions and concerns over the recent cases of the deadly Ebola virus in the United States, KPIX 5’s interview with Dr. Charles Chiu, an expert on infectious diseases at University of California at San Francisco may provide answers.




Diagnosis of neuroleptospirosis by next-generation sequencing (June 5th, 2014)



Experimental DNA test helps diagnose teen from Cottage Grove, Wisconsin


Next-generation genomic sequencing tests for viruses, bacteria, fungi (June 11th, 2014).




SURPI

Developed by the Chiu laboratory, SURPI is a new bioinformatics pipeline for rapid pathogen identification from next-generation sequencing data (June 4th, 2014).




CNN Erin Burnett Outfront


Yosemite warns of deadly virus linked to rodents (September 11th, 2012).




Virus mutation: California Academy of Sciences


Scientists are working hard to keep up on how viruses mutate especially with the recent outbreak of the H1N1 influenza virus (June 30, 2009).